Transport for London is cutting the frequency of bus route 47 (Bellingham to Liverpool Street via Surrey Quays and Jamaica Road).
From Saturday 30 September, the Monday-Saturday daytime frequency will be reduced from six buses an hour to five.
During the evenings and on Sundays, buses will run just three times an hour instead of every 15 minutes.
TfL says it is making the change “to better match how often buses run with demand for them”.